![]() ![]() ![]() Caution should be taken in people with asthma or glaucoma and it is not recommended in those who have had a prior C-section. In babies there may be decreased breathing and low blood pressure. Ĭommon side effects of PGE2 include nausea, vomiting, diarrhea, fever, and excessive uterine contraction. Specifically, prostaglandin G2 (PGG 2) is modified by the peroxidase moiety of the COX enzyme to produce prostaglandin H2 (PGH 2) which is then converted to PGE2. Once activated, AA is oxygenated by cyclooxygenase (COX) enzymes to form prostaglandin endoperoxides. PGE2 synthesis within the body begins with the activation of arachidonic acid (AA) by the enzyme phospholipase A2. ![]() It may be used within the vagina or by injection into a vein. It is also used to manage gestational trophoblastic disease. In babies it is used in those with congenital heart defects until surgery can be carried out. Dinoprostone is used in labor induction, bleeding after delivery, termination of pregnancy, and in newborn babies to keep the ductus arteriosus open. Prostaglandin E 2 ( PGE2), also known as dinoprostone, is a naturally occurring prostaglandin with oxytocic properties that is used as a medication.
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